Abdominal Obesity and the Endocannabinoid System: From Basic by Jean-Pierre Despres, Vincenzo Di Marzo

By Jean-Pierre Despres, Vincenzo Di Marzo

This across the world popular writer staff offers a special and thorough research and distillation of the endocannabinoid process and its dating to stomach weight problems, diabetes, and heart problems. The endocannabinoid procedure (ECS) performs a major function in cardiometabolic danger, in addition to modulating strength stability, feeding habit, hepatic lipogenesis, and maybe glucose homeostasis. facts means that the ECS is overactive in human weight problems and dyslipidemia. severe to the administration of cardiometabolic probability, this new, well timed ebook presents functional overviews and administration suggestions on many very important issues, together with: stomach weight problems and the metabolic syndrome the endocannabinoid process and effort stability: features and dysfunctions stomach weight problems, the EC approach, and cardiometabolic danger

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Extra info for Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk

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WEIGHT LOSS Regardless of the mechanisms involved, weight loss in obese individuals is associated with a decrease in blood pressure. In 50% or more of individuals, the average decrease in diastolic blood pressure is 1–4 mmHg systolic and 1–2 mmHg diastolic per kilogram of weight reduction as normalization of blood pressure (54–56). It is noticed that after the weight loss has ceased, the persistent effect of weight loss on blood pressure may not always be encountered (57,58). OBESITY AND HYPERTENSION 23 CONCLUSION Obesity alone does not appear to be responsible for an increase in blood pressure.

5 years of follow-up of the participants in the study of men born in 1913. Diabetes 1985; 34:1055–1058. 18. Lundgren H, Bengtsson C, Blohme G, et al. Adiposity and adipose tissue distribution in relation to incidence of diabetes in women: Results from a prospective population study in Gothenburg, Sweden. Int J Obes 1989; 13(4):413–423. 19. Balkau B, Deanfield JE, Despr´es JP, et al. International Day for the Evaluation of Abdominal Obesity (IDEA): A study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries.

23. Eguchi Y, Eguchi T, Mizuta T, et al. Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. J Gastroenterol 2006; 41:462–469. 24. Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115(5):1343–1351. 25. Barrows BR, Parks EJ. Contributions of different fatty acid sources to very low-density lipoproteintriglycerol in the fasted and fed states.

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