Advances in Bioengineering by Pier Andrea Serra

By Pier Andrea Serra

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81] modified silicon surfaces with allylamine dielectric barrier discharge and microwave plasma respectively. After plasma exposure, the 35 36 Advances in Bioengineering contact angle decreased considerably due to the formation of various nitrogen functionalities as determined by FTIR. Cell culture tests with fibroblasts showed that both cell adhesion as well as cell proliferation could be improved by allylamine plasma treatment. Comparable results were obtained by Zelzer et al. [82] using glass substrates.

And for the same plasma treatment, a different plasma media will also yield specific surface characteristics. Moreover, a specific type of cell reacts differently with specific surface properties. Cell adhesion and proliferation on amine plasma polymer films deposited onto different substrates have been widely investigated. Different plasma methods have been used and different cells and biomolecules interactions with the treated surfaces have been investigated for various biomedical applications.

In contrast, films from allylamine grow smoothly from the very earliest stages. Moreover, it has been found that monomers containing double bonds polymerize faster in plasma than their saturated counterparts. Gancarz et al. [25] have investigated the plasma polymerization of n-butylamine and allyla‐ mine and observed that the deposited layers are much thicker for allylamine plasmas. This observation has also been confirmed in a study performed by Mangindaan et al. [60]. 5. Interaction between plasma induced amino groups and cells In this section, an overview of literature on plasma treatments used for the incorporation of amine functionalities and their influence on cell-material interactions will be given.

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