Advances in Clinical Chemistry, Vol. 32 by Herbert E. Spiegel

By Herbert E. Spiegel

Compliment for the sequence: "Its continuity of pertinence, excellence, and authority is still unbroken - a tribute to the skilful enhancing and writing concerned. each knowledgeable laboratory employees should have to be had a duplicate of this volume." --Clinical Chemistry For greater than thirty years, this serial has broadened the technical scope and multiplied the medical base of scientific chemistry. those volumes make clear the parts of molecular biology, informatics, and the tracking of physiological parameters in serious events as they pertain to medical chemistry. every one quantity of Advances in medical Chemistry comprises an index, and every bankruptcy comprises references.

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39 Copynghi 0 1996 by Academic Press, Inc All nzhts of re~roductiontn anv form reserved 40 KAISER J. AZIZ (hematology, microbiology, virology, tissue typing) and that have applications for genetic disorders, oncology, transplantation, and infectious diseases. Examples are nucleic acid hybridization (dot blot, Southern blot), in situ hybridization, and in vitro amplification technologies such as the polymerase chain reaction (PCR). Probes based on DNA analysis are now available for several important genetic disorders such as cystic fibrosis, muscular dystrophies, fragile X syndrome, sickle-cell anemia, Gaucher’s disease, and Huntington’s chorea.

Science 252, 1179-1 181 (1991). Z I . Zumwalt, R. , Application of molecular biology to forensic pathology. Hum. Purhol. 20, 303-307 (1989). ADVANCES I N CLINICAL CHEMISTRY, VOL. 32 CLINICAL MOLECULAR BIOLOGY: CONCEPTS AND APPLICATIONS Kaiser J. kit" Division of Clinical laboratory Devices Food and Drug Administration Rockville, Maryland 1. Introduction .. .. of Diseases . . . . . . , . , . . . , . , . , Cystic Fibrosis . . . . . . . . . . . . . . . . . . . . . . .

B8. Bishop, J. , Molecular themes in oncogenesis. ) 64, 235-248 ( I 991 ). B9. , White, R. , and Davis, R. , Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Gener. 32, 314-331 (1980). B 10. , and Haase, A. , Detection of viral sequences of low reiteration frequency by in situ hybridization. Proc. Nafl. Acad. Sci. A. 75, 6125-6129 (1978). B I I . Buffone, G. , and Darlington, G. , Isolation of DNA from biological specimens without extraction with phenol.

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